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BDA-410: A novel synthetic calpain inhibitor active against blood stage malaria

Falcipains, the papain-family cysteine proteases of the Plasmodium falciparum, are potential drug targets for malaria parasite. Pharmacological inhibition of falcipains can block the hydrolysis of hemoglobin, parasite development, and egress, suggesting that falcipains play a key role at the blood s...

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Detalhes bibliográficos
Main Authors: Li, Xuerong, Chen, Huiqing, Jeong, Jong-Jin, Chishti, Athar H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1993804/
https://ncbi.nlm.nih.gov/pubmed/17583361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2007.05.004
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