PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice

Phenylketonuria (PKU) is a common genetic disorder in humans that arises from deficient activity of phenylalanine hydroxylase (PAH), which catalyzes the conversion of phenylalanine to tyrosine. There is a resultant hyperphenylalanemia with subsequent impairment in cognitive abilities, executive func...

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Hlavní autoři: Embury, Jennifer E., Charron, Catherine E., Martynyuk, Anatoly, Zori, Andreas G., Liu, Bin, Ali, Syed F., Rowland, Neil E., Laipis, Philip J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1992743/
https://ncbi.nlm.nih.gov/pubmed/17112485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2006.09.101
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