Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching

IL-4 and CD40 ligation are essential for IgE synthesis by B cells. We have shown previously that hydrocortisone (HC) induces IgE synthesis in IL-4–stimulated human B cells. In this study we demonstrate that HC fails to induce IgE synthesis in B cells from CD40 ligand–deficient (CD40L-deficient) pati...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Jabara, Haifa H., Brodeur, Scott R., Geha, Raif S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC199190/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11160161/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI10168
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