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Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching

IL-4 and CD40 ligation are essential for IgE synthesis by B cells. We have shown previously that hydrocortisone (HC) induces IgE synthesis in IL-4–stimulated human B cells. In this study we demonstrate that HC fails to induce IgE synthesis in B cells from CD40 ligand–deficient (CD40L-deficient) pati...

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Udgivet i:J Clin Invest
Principais autores: Jabara, Haifa H., Brodeur, Scott R., Geha, Raif S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC199190/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11160161/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI10168
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