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Effect of Cellular Quiescence on the Success of Targeted CML Therapy

BACKGROUND: Similar to tissue stem cells, primitive tumor cells in chronic myelogenous leukemia have been observed to undergo quiescence; that is, the cells can temporarily stop dividing. Using mathematical models, we investigate the effect of cellular quiescence on the outcome of therapy with targe...

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書誌詳細
主要な著者: Komarova, Natalia L., Wodarz, Dominik
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1991595/
https://ncbi.nlm.nih.gov/pubmed/17912367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000990
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