Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis

Statins are a class of drugs that inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMGcoA) reductase, a critical enzyme in the mevalonate pathway. Several reports document that statins may prevent different human cancers. However, whether or not statins can prevent cancer is controversial due to disco...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Shachaf, Catherine M., Perez, Omar D., Youssef, Sawsan, Fan, Alice C., Elchuri, Sailaja, Goldstein, Matthew J., Shirer, Amy E., Sharpe, Orr, Chen, Joy, Mitchell, Dennis J., Chang, Maria, Nolan, Garry P., Steinman, Lawrence, Felsher, Dean W.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society of Hematology 2007
Θέματα:
Neoplasia
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988916/
https://ncbi.nlm.nih.gov/pubmed/17622571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-09-048033
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