Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis

Statins are a class of drugs that inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMGcoA) reductase, a critical enzyme in the mevalonate pathway. Several reports document that statins may prevent different human cancers. However, whether or not statins can prevent cancer is controversial due to disco...

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Main Authors: Shachaf, Catherine M., Perez, Omar D., Youssef, Sawsan, Fan, Alice C., Elchuri, Sailaja, Goldstein, Matthew J., Shirer, Amy E., Sharpe, Orr, Chen, Joy, Mitchell, Dennis J., Chang, Maria, Nolan, Garry P., Steinman, Lawrence, Felsher, Dean W.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2007
主題:
Neoplasia
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988916/
https://ncbi.nlm.nih.gov/pubmed/17622571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-09-048033
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