Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis

Statins are a class of drugs that inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMGcoA) reductase, a critical enzyme in the mevalonate pathway. Several reports document that statins may prevent different human cancers. However, whether or not statins can prevent cancer is controversial due to disco...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shachaf, Catherine M., Perez, Omar D., Youssef, Sawsan, Fan, Alice C., Elchuri, Sailaja, Goldstein, Matthew J., Shirer, Amy E., Sharpe, Orr, Chen, Joy, Mitchell, Dennis J., Chang, Maria, Nolan, Garry P., Steinman, Lawrence, Felsher, Dean W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2007
Pynciau:
Neoplasia
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988916/
https://ncbi.nlm.nih.gov/pubmed/17622571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-09-048033
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