Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis

Statins are a class of drugs that inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMGcoA) reductase, a critical enzyme in the mevalonate pathway. Several reports document that statins may prevent different human cancers. However, whether or not statins can prevent cancer is controversial due to disco...

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Autors principals: Shachaf, Catherine M., Perez, Omar D., Youssef, Sawsan, Fan, Alice C., Elchuri, Sailaja, Goldstein, Matthew J., Shirer, Amy E., Sharpe, Orr, Chen, Joy, Mitchell, Dennis J., Chang, Maria, Nolan, Garry P., Steinman, Lawrence, Felsher, Dean W.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2007
Matèries:
Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988916/
https://ncbi.nlm.nih.gov/pubmed/17622571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-09-048033
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