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Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNγ/Stat1 signals
T-bet plays a critical role in controlling IFNγ expression, Th1 polarization, and CD8 cytolytic development. Its regulation has been demonstrated to be mostly IFNγ/Stat1 dependent while IL-12/Stat4 independent. Here we show that IL-12/Stat4 binds to a distant highly conserved STAT-responsive T-bet e...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1988915/ https://ncbi.nlm.nih.gov/pubmed/17575072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-11-058271 |
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