Stable Complexes Formed by HIV-1 Reverse Transcriptase at Distinct Positions on the Primer-Template Controlled by Binding Deoxynucleoside Triphosphates or Foscarnet

Binding of the next complementary dNTP by the binary complex containing HIV-1 reverse transcriptase (RT) and primer-template induces conformational changes that have been implicated in catalytic function of RT. We have used DNase I footprinting, gel electrophoretic mobility shift, and exonuclease pr...

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Hauptverfasser: Meyer, Peter R., Rutvisuttinunt, Wiriya, Matsuura, Suzanne E., So, Antero G., Scott, Walter A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1986715/
https://ncbi.nlm.nih.gov/pubmed/17400246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.03.006
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