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Getting specificity from simplicity in putative proteins from the prebiotic Earth

Can unique protein structures arise from a limited set of amino acids present on the prebiotic Earth? To address this question, we have determined the stability and structure of KIA7, a 20-residue polypeptide containing chiefly Lys, Ile, and Ala. NMR methods reveal that KIA7 tetramerizes and folds o...

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Autors principals: López de la Osa, Jaime, Bateman, David A., Ho, Sylvia, González, Carlos, Chakrabartty, Avijit, Laurents, Douglas V.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1986592/
https://ncbi.nlm.nih.gov/pubmed/17855563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706876104
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