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Gene rearrangement attenuates expression and lethality of a nonsegmented negative strand RNA virus

The nonsegmented negative strand RNA viruses comprise hundreds of human, animal, insect, and plant pathogens. Gene expression of these viruses is controlled by the highly conserved order of genes relative to the single transcriptional promoter. We utilized this regulatory mechanism to alter gene exp...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wertz, Gail Williams, Perepelitsa, Victoria P., Ball, L. Andrew
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19865/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9520395/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.7.3501
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