Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice

It has been suggested that increased collagenase-3 (MMP-13) activity plays a pivotal role in the pathogenesis of osteoarthritis (OA). We have used tetracycline-regulated transcription in conjunction with a cartilage-specific promoter to target a constitutively active human MMP-13 to the hyaline cart...

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Detalhes bibliográficos
Main Authors: Neuhold, Lisa A., Killar, Loran, Zhao, Weiguang, Sung, Mei-Li A., Warner, Linda, Kulik, John, Turner, James, Wu, William, Billinghurst, C., Meijers, T., Poole, A. Robin, Babij, Philip, DeGennaro, Louis J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC198546/
https://ncbi.nlm.nih.gov/pubmed/11134178
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