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Evidence that IGF-binding protein-5 functions as a growth factor

Recent studies support the concept that IGF-binding protein-5 (IGFBP-5) stimulates bone formation, at least in part, via IGF-independent mechanisms. To evaluate this hypothesis further, we evaluated in vitro and in vivo effects of IGFBP-5 on bone formation parameters using the IGF-I knockout (KO) mo...

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Autors principals: Miyakoshi, Naohisa, Richman, Charmaine, Kasukawa, Yuji, Linkhart, Thomas A., Baylink, David J., Mohan, Subburaman
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC198544/
https://ncbi.nlm.nih.gov/pubmed/11134182
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