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Creatine kinase: Essential arginine residues at the nucleotide binding site identified by chemical modification and high-resolution tandem mass spectrometry

Phenylglyoxal is an arginine-specific reagent that inactivates creatine kinase (CK). Previous results suggest that modification of the dimeric enzyme at a single arginine residue per subunit causes complete inactivation accompanied by the loss of nucleotide binding; the actual site of modification w...

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Autori principali: Wood, Troy D., Guan, Ziqiang, Borders, Charles L., Chen, Lorenzo H., Kenyon, George L., McLafferty, Fred W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC19840/
https://ncbi.nlm.nih.gov/pubmed/9520370
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