Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase

Depudecin is a fungal metabolite that reverts the rounded phenotype of NIH 3T3 fibroblasts transformed with v-ras and v-src oncogenes to the flattened phenotype of the nontransformed parental cells. The mechanism of detransformation induced by this agent had not been determined. Here, we demonstrate...

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Bibliographic Details
Main Authors: Kwon, Ho Jeong, Owa, Takashi, Hassig, Christian A., Shimada, Junichi, Schreiber, Stuart L.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1998
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC19839/
https://ncbi.nlm.nih.gov/pubmed/9520369
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