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Constraint-Based Modeling and Kinetic Analysis of the Smad Dependent TGF-β Signaling Pathway

BACKGROUND: Investigation of dynamics and regulation of the TGF-β signaling pathway is central to the understanding of complex cellular processes such as growth, apoptosis, and differentiation. In this study, we aim at using systems biology approach to provide dynamic analysis on this pathway. METHO...

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Autors principals: Zi, Zhike, Klipp, Edda
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978528/
https://ncbi.nlm.nih.gov/pubmed/17895977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000936
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