Hybrid Homology Modeling and Mutational Analysis of Cytochrome P450C24A1 (CYP24A1) of the Vitamin D Pathway: Insights into Substrate Specificity and Membrane Bound Structure-Function

Cytochrome P450C24A1 (CYP24A1), a peripheral inner mitochondrial membrane hemoprotein and candidate oncogene, regulates the side-chain metabolism and biological function of vitamin D and many of its related analog drugs. Rational mutational analysis of rat CYP24A1 based on hybrid (2C5/BM-3) homology...

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Detalhes bibliográficos
Main Authors: Annalora, Andrew J., Bobrovnikova-Marjon, Ekaterina, Serda, Rita, Pastuszyn, Andrzej, Graham, Sandra E., Marcus, Craig B., Omdahl, John L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978416/
https://ncbi.nlm.nih.gov/pubmed/17207766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2006.11.018
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