Tachyphylaxis of the ECL-cell response to PACAP: receptor desensitization and/or depletion of secretory products

BACKGROUND AND PURPOSE: Rat stomach ECL cells secrete histamine and pancreastatin in response to gastrin and pituitary adenylate cyclase-activating peptide-27 (PACAP). This study applies microdialysis to explore how ECL cells in situ respond to PACAP and gastrin. EXPERIMENTAL APPROACH: Both peptides...

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Bibliographic Details
Main Authors: Bernsand, M, Håkanson, R, Norlén, P
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2007
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978265/
https://ncbi.nlm.nih.gov/pubmed/17660849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707385
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