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Structure of the complex of porcine pancreatic elastase with a trimacrocyclic peptide inhibitor FR901451
Porcine pancreatic elastase (PPE) resembles the attractive drug target leukocyte elastase, which has the ability to degrade connective tissue in the body. The crystal structure of PPE complexed with a novel trimacrocyclic peptide inhibitor, FR901451, was solved at 1.9 Å resolution. The inhibitor occ...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1978120/ https://ncbi.nlm.nih.gov/pubmed/16511165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309105026047 |
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