The renal effects of N10-propargyl-5,8-dideazafolic acid (CB3717) and a non-nephrotoxic analogue ICI D1694, in mice.

N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)- N-methylamino]-2-thenoyl)-L-glutamic acid (ICI D1694) is an analogue of the thymidylate synthase inhibitor, N10-propargyl-5,8-dideazafolic acid (CB3717). CB3717 was found to be active in early clinical studies, but its use was limited by nep...

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Main Authors: Jodrell, D. I., Newell, D. R., Morgan, S. E., Clinton, S., Bensted, J. P., Hughes, L. R., Calvert, A. H.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1991
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1977485/
https://ncbi.nlm.nih.gov/pubmed/1931603
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