A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA

CpG-DNA or its synthetic analog CpG-ODN activates innate immunity through Toll-like receptor 9 (TLR9). However, the mechanism of TLR9 activation by CpG-DNA remains elusive. Here we have identified HMGB1 as a CpG-ODN–binding protein. HMGB1 interacts and preassociates with TLR9 in the endoplasmic reti...

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Detalhes bibliográficos
Main Authors: Ivanov, Stanimir, Dragoi, Ana-Maria, Wang, Xin, Dallacosta, Corrado, Louten, Jennifer, Musco, Giovanna, Sitia, Giovanni, Yap, George S., Wan, Yinsheng, Biron, Christine A., Bianchi, Marco E., Wang, Haichao, Chu, Wen-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976374/
https://ncbi.nlm.nih.gov/pubmed/17548579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-09-044776
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