Adenoviral vectors persist in vivo and maintain activated CD8(+) T cells: implications for their use as vaccines

CD8(+) T cell-numbers rapidly expand and then contract after exposure to their cognate antigen. Here we show that the sustained frequencies of transgene product-specific CD8(+) T cells elicited by replication-defective adenovirus vectors are linked to persistence of low levels of transcriptionally a...

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Hlavní autoři: Tatsis, Nia, Fitzgerald, Julie C., Reyes-Sandoval, Arturo, Harris-McCoy, Kimberly C., Hensley, Scott E., Zhou, Dongming, Lin, Shih-Wen, Bian, Ang, Xiang, Zhi Quan, Iparraguirre, Amaya, Lopez-Camacho, Cesar, Wherry, E. John, Ertl, Hildegund C. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2007
Témata:
Immunobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976365/
https://ncbi.nlm.nih.gov/pubmed/17510320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-02-062117
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