Farnesyl transferase inhibitor resistance probed by target mutagenesis

Mutation in the target oncoprotein is a common mechanism of resistance to tyrosine kinase inhibitors, as exemplified by the many BCR/ABL mutations that thwart imatinib activity in patients with chronic myelogenous leukemia. It remains unclear whether normal cellular protein targets of chemotherapeut...

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Bibliographic Details
Main Authors: Raz, Tal, Nardi, Valentina, Azam, Mohammad, Cortes, Jorge, Daley, George Q.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2007
Subjects:
Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976354/
https://ncbi.nlm.nih.gov/pubmed/17536018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-12-064907
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