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Temperature-dependent heme kinetics with nonexponential binding and barrier relaxation in the absence of protein conformational substates

We present temperature-dependent kinetic measurements of ultrafast diatomic ligand binding to the “bare” protoheme (L(1)-FePPIX-L(2), where L(1) = H(2)O or 2-methyl imidazole and L(2) = CO or NO). We found that the binding of CO is temperature-dependent and nonexponential over many decades in time,...

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Detalhes bibliográficos
Main Authors: Ye, Xiong, Ionascu, Dan, Gruia, Florin, Yu, Anchi, Benabbas, Abdelkrim, Champion, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976205/
https://ncbi.nlm.nih.gov/pubmed/17804802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702622104
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