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Reduction in PU.1 Activity Results in a Block to B Cell Development, Abnormal Myeloid Proliferation, and Neonatal Lethality
OBJECTIVE: It has been demonstrated that high concentration of the transcription factor PU.1 (encoded by Sfpi1) promotes macrophage development, whereas low concentration induces B cell development in vitro. This has led to the hypothesis that lower levels of PU.1 activity are required for B cell th...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1975786/ https://ncbi.nlm.nih.gov/pubmed/17588474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2007.04.005 |
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