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α(2)-macroglobulin associates with β-amyloid peptide and prevents fibril formation
We have used the yeast two-hybrid system to isolate cDNAs encoding proteins that specifically interact with the 42-aa β-amyloid peptide (Aβ), a major constituent of senile plaques in Alzheimer’s disease. The carboxy terminus of α(2)-macroglobulin (α2M), a proteinase inhibitor released in response to...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences
1998
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC19732/ https://ncbi.nlm.nih.gov/pubmed/9501253 |
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