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Ntr1 activates the Prp43 helicase to trigger release of lariat-intron from the spliceosome
DEAD/H-box NTPases remodel the spliceosome at multiple steps during the pre-mRNA splicing cycle. The RNA-dependent NTPase Prp43 catalyzes dissociation of excised lariat-intron from the spliceosome, but it is unclear how Prp43 couples the energy of ATP hydrolysis to intron release. Here, we report th...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1973145/ https://ncbi.nlm.nih.gov/pubmed/17875666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1580507 |
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