Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression

BACKGROUND: In vivo studies on HIV-1 pathogenesis and testing of antiviral strategies have been hampered by the lack of an immunocompetent small animal model that is highly susceptible to HIV-1 infection. Since native rodents are non-permissive, we developed transgenic rats that selectively express...

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Bibliographische Detailangaben
Hauptverfasser: Goffinet, Christine, Michel, Nico, Allespach, Ina, Tervo, Hanna-Mari, Hermann, Volker, Kräusslich, Hans-Georg, Greene, Warner C, Keppler, Oliver T
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2007
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1971067/
https://ncbi.nlm.nih.gov/pubmed/17655755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-4-53
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