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Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules

How memory T cells are maintained in vivo is poorly understood. To address this problem, a male-specific peptide (H-Y) was identified and used to activate female anti-H-Y T cells in vitro. Anti-H-Y T cells survived in vivo for at least 70 days in the absence of antigen. This persistence was not beca...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Markiewicz, Mary A., Girao, Cristina, Opferman, Joseph T., Sun, Jiling, Hu, Qinghui, Agulnik, Alexander A., Bishop, Colin E., Thompson, Craig B., Ashton-Rickardt, Philip G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1998
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19695/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9501216/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.6.3065
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