Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa

In addition to inhibiting cyclooxygenase (COX)-1-derived prostanoid biosynthesis, aspirin acetylates COX-2, enabling the conversion of arachidonic acid to 15(R)-epi lipoxin A(4), or aspirin-triggered lipoxin (ATL). Selective COX-2 inhibitors block ATL formation and exacerbate mucosal injury in rats...

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Main Authors: Fiorucci, Stefano, Santucci, Luca, Wallace, John L., Sardina, Marco, Romano, Mario, del Soldato, Piero, Morelli, Antonio
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2003
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC196906/
https://ncbi.nlm.nih.gov/pubmed/12960371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1933204100
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