Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice

SPA-1 is a principal Rap1 GTPase-activating protein in the hematopoietic progenitors and peripheral T cells, and SPA-1-deficient mice develop a spectrum of myeloproliferative stem cell disorders of late onset. In the present study, we show that SPA-1-deficient mice develop age-dependent T cell unres...

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Bibliografiske detaljer
Main Authors: Ishida, Daisuke, Yang, Hailin, Masuda, Kyoko, Uesugi, Kanami, Kawamoto, Hiroshi, Hattori, Masakazu, Minato, Nagahiro
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC196903/
https://ncbi.nlm.nih.gov/pubmed/12958214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1834525100
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