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Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

Only a small number of T cells generated in the thymus each day are selected to replenish the peripheral T cell pool. Much is known about thymic selection; however, little is known of the mechanisms regulating medullary maturation and the release of mature T cells into the blood. Here we demonstrate...

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Detalhes bibliográficos
Main Authors: Rosen, Hugh, Alfonso, Christopher, Surh, Charles D., McHeyzer-Williams, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196901/
https://ncbi.nlm.nih.gov/pubmed/12954982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1832725100
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