Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2

Stimulation of a mutant angiotensin type 1A receptor (DRY/AAY) with angiotensin II (Ang II) or of a wild-type receptor with an Ang II analog ([sarcosine(1),Ile(4),Ile(8)]Ang II) fails to activate classical heterotrimeric G protein signaling but does lead to recruitment of β-arrestin 2-GFP and activa...

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Bibliographic Details
Main Authors: Wei, Huijun, Ahn, Seungkirl, Shenoy, Sudha K., Karnik, Sadashiva S., Hunyady, László, Luttrell, Louis M., Lefkowitz, Robert J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC196880/
https://ncbi.nlm.nih.gov/pubmed/12949261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1834556100
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