Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells.

Doxorubicin accumulation defects in multidrug resistant tumour cells are generally small in comparison to the resistance factors. Therefore additional mechanisms must be operative. In this paper we show by a quantitative approach that doxorubicin resistance in several P-glycoprotein-positive non-sma...

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Main Authors: Schuurhuis, G. J., van Heijningen, T. H., Cervantes, A., Pinedo, H. M., de Lange, J. H., Keizer, H. G., Broxterman, H. J., Baak, J. P., Lankelma, J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968747/
https://ncbi.nlm.nih.gov/pubmed/8105865
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