Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription
Axin antagonizes the developmental effects of Wnt in vertebrates. We show here that Axin simultaneously binds two components of the Wnt pathway, β-catenin and its negative regulator glycogen synthase kinase-3β. In mammalian cells, Axin inhibits Wnt-1 stimulation of β-catenin/lymphoid enhancer factor...
שמור ב:
| הוצא לאור ב: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
1998
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19687/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9501208/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.6.3020 |
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