Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis

UV irradiation induces apoptosis in U937 human leukemic cells that is accompanied by the activation of both the stress-activated protein kinase (SAPK) and p38 mitogen-activated protein kinase (MAPK) signal transduction pathways. The MAPK phosphatase, MKP-1, is capable of inactivating both SAPK and p...

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Detalles Bibliográficos
Main Authors: Franklin, Christopher C., Srikanth, Sampathkumar, Kraft, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC19686/
https://ncbi.nlm.nih.gov/pubmed/9501207
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