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Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles

Sterols mediate feedback inhibition of the sterol regulatory element-binding protein (SREBP) pathway by preventing movement of the SREBP cleavage-activating protein (SCAP)/SREBP complex from endoplasmic reticulum (ER) to Golgi, where proteolytic cleavage of SREBPs releases the transcription factor d...

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Tallennettuna:
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Adams, Christopher M., Goldstein, Joseph L., Brown, Michael S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2003
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196858/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12963821/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1534833100
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