Targeting of saporin to CD25-positive normal and neoplastic lymphocytes by an anti-saporin/anti-CD25 bispecific monoclonal antibody: in vitro evaluation.

This study has been designed to verify the specific toxicity of saporin, a type 1 ribosome-inactivating protein (RIP), with the same activity as ricin A chain, targeted by a bispecific monoclonal antibody (bimAb) recognising both the CD25 antigen and the RIP. The CD25 antigen is expressed by lymphoi...

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Main Authors: Tazzari, P. L., Zhang, S., Chen, Q., Sforzini, S., Bolognesi, A., Stirpe, F., Xie, H., Moretta, A., Ferrini, S.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1993
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968507/
https://ncbi.nlm.nih.gov/pubmed/8512810
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