Prognostic significance of TP53 alterations in breast carcinoma.

Constant denaturant gel electrophoresis (CDGE) was used to screen 179 breast carcinomas for mutations in the conserved regions of the TP53 gene (exons 5 through 8). Mutations were found in 35 of 163 primary tumours (21%) and in 5 of 16 metastases (31%) and resided predominantly in exon 7. The majori...

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Main Authors: Andersen, T. I., Holm, R., Nesland, J. M., Heimdal, K. R., Ottestad, L., Børresen, A. L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968415/
https://ncbi.nlm.nih.gov/pubmed/8102535
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