Prognostic significance of TP53 alterations in breast carcinoma.

Constant denaturant gel electrophoresis (CDGE) was used to screen 179 breast carcinomas for mutations in the conserved regions of the TP53 gene (exons 5 through 8). Mutations were found in 35 of 163 primary tumours (21%) and in 5 of 16 metastases (31%) and resided predominantly in exon 7. The majori...

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Bibliografiska uppgifter
Huvudupphovsmän: Andersen, T. I., Holm, R., Nesland, J. M., Heimdal, K. R., Ottestad, L., Børresen, A. L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 1993
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968415/
https://ncbi.nlm.nih.gov/pubmed/8102535
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