Comparative radioimmunotherapy using intact or F(ab')2 fragments of 131I anti-CEA antibody in a colonic xenograft model.

The therapeutic efficacy of intact and F(ab')2 fragments of a 131I anti-CEA antibody were compared in an established LS174T colonic xenograft model in nude mice. A single IV dose of either 0.5 mCi (18.5 MBq) intact or 1.0 mCi (37 MBq) F(ab')2 fragments significantly delayed tumour growth,...

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Main Authors: Pedley, R. B., Boden, J. A., Boden, R., Dale, R., Begent, R. H.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1993
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968289/
https://ncbi.nlm.nih.gov/pubmed/8318423
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