Preclinical, phase I and pharmacokinetic studies with the dimethyl phenyltriazene CB10-277.

Decarbazine is an imidazole dimethyltriazene with reproducible activity in patients with metastatic melanoma. CB10-277 is a phenyl dimethyltriazene which, like dacarbazine, requires metabolic activation to its corresponding monomethyl species for antitumour activity. In preclinical models (human mel...

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Bibliographic Details
Main Authors:	Foster, B. J., Newell, D. R., Carmichael, J., Harris, A. L., Gumbrell, L. A., Jones, M., Goodard, P. M., Calvert, A. H.
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 1993
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1968184/ https://ncbi.nlm.nih.gov/pubmed/8431367
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Preclinical, phase I and pharmacokinetic studies with the dimethyl phenyltriazene CB10-277.

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