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Histone Hyperacetylation in Mitosis Prevents Sister Chromatid Separation and Produces Chromosome Segregation Defects

Posttranslational modifications of core histones contribute to driving changes in chromatin conformation and compaction. Herein, we investigated the role of histone deacetylation on the mitotic process by inhibiting histone deacetylases shortly before mitosis in human primary fibroblasts. Cells ente...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Biol Cell
Prif Awduron: Cimini, Daniela, Mattiuzzo, Marta, Torosantucci, Liliana, Degrassi, Francesca
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Cell Biology 2003
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196571/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12972566/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E03-01-0860
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