R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

The R-Spondin (RSpo) family of secreted proteins act as potent activators of the Wnt/β-catenin signaling pathway. We have previously shown that RSpo proteins can induce proliferative effects on the gastrointestinal epithelium in mice. Here we provide a mechanism whereby RSpo1 regulates cellular resp...

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Bibliographic Details
Main Authors: Binnerts, Minke E., Kim, Kyung-Ah, Bright, Jessica M., Patel, Sejal M., Tran, Karolyn, Zhou, Mei, Leung, John M., Liu, Yi, Lomas, Woodrow E., Dixon, Melissa, Hazell, Sophie A., Wagle, Marie, Nie, Wen-Sheng, Tomasevic, Nenad, Williams, Jason, Zhan, Xiaoming, Levy, Michael D., Funk, Walter D., Abo, Arie
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1965484/
https://ncbi.nlm.nih.gov/pubmed/17804805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702305104
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