Calcium Block of Single Sodium Channels: Role of a Pore-Lining Aromatic Residue

Extracellular Ca(2+) ions cause a rapid block of voltage-gated sodium channels, manifest as an apparent reduction of the amplitude of single-channel currents. We examined the influence of residue Tyr-401 in the isoform rNa(V)1.4 on both single-channel conductance and Ca(2+) block. An aromatic residu...

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Autores principales: Santarelli, Vincent P., Eastwood, Amy L., Dougherty, Dennis A., Ahern, Christopher A., Horn, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: Biophysical Society 2007
Materias:
Channels, Receptors, and Electrical Signaling
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1965434/
https://ncbi.nlm.nih.gov/pubmed/17545248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.106856
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