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Calcium Block of Single Sodium Channels: Role of a Pore-Lining Aromatic Residue
Extracellular Ca(2+) ions cause a rapid block of voltage-gated sodium channels, manifest as an apparent reduction of the amplitude of single-channel currents. We examined the influence of residue Tyr-401 in the isoform rNa(V)1.4 on both single-channel conductance and Ca(2+) block. An aromatic residu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1965434/ https://ncbi.nlm.nih.gov/pubmed/17545248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.106856 |
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