Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes

PRC2 is thought to be the histone methyltransferase (HMTase) responsible for H3-K27 trimethylation at Polycomb target genes. Here we report the biochemical purification and characterization of a distinct form of Drosophila PRC2 that contains the Polycomb group protein polycomblike (Pcl). Like PRC2,...

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Auteurs principaux: Nekrasov, Maxim, Klymenko, Tetyana, Fraterman, Sven, Papp, Bernadett, Oktaba, Katarzyna, Köcher, Thomas, Cohen, Adrian, Stunnenberg, Hendrik G, Wilm, Matthias, Müller, Jürg
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1964751/
https://ncbi.nlm.nih.gov/pubmed/17762866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601837
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