Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal–ventral axis in the limb

By conditional gene ablation in mice, we found that β-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal–ventral axis of the limbs. By generation of compound mutants, we also show that β-catenin...

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Detalhes bibliográficos
Main Authors: Soshnikova, Natalia, Zechner, Dietmar, Huelsken, Joerg, Mishina, Yuji, Behringer, Richard R., Taketo, Makoto M., Crenshaw, E. Bryan, Birchmeier, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196251/
https://ncbi.nlm.nih.gov/pubmed/12923052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.263003
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